Amylin reduces plasma glucagon concentration in cats
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چکیده
منابع مشابه
Amylin reduces plasma glucagon concentration in cats.
Pancreatic amylin plays an important role in the control of nutrient fluxes and is an established therapy in human diabetes as it reduces post-prandial glucagon secretion and slows gastric emptying. Given the similar pathophysiology of human type-2 and feline diabetes mellitus, we investigated whether amylin reduces plasma glucagon levels in cats. Healthy cats were tested using an intravenous a...
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Recent interest has focused on the potential role of amylin in the pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM). This 37-amino acid peptide is found in extracellular amyloid deposits in approximately 50% of pancreatic islets of patients with NIDDM and has been shown to inhibit skeletal muscle glycogen synthesis in vitro. Immunocytochemical studies have colocalized amylin and ...
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The propensity of diets of different composition to promote obesity is a current topic in feline medicine. The effects of three meals with different protein:fat ratios on hormones (insulin, acylated ghrelin and amylin) involved in the control of food intake and glucose metabolism were compared. Five lean (two females and three males, 28.6 (sd 3.4) % body fat mass (BFM), mean body weight (BW) 45...
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OBJECTIVE Given the interest in glucagon antagonism as a potential treatment of diabetes, we tested the hypothesis that glucagon, in concert with insulin, supports the postabsorptive plasma glucose concentration in humans. RESEARCH DESIGN AND METHODS Following preliminary studies that indicated that a peripheral intravenous insulin dose of 0.1 mU x kg(-1) x min(-1) (lower than those used prev...
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... ... ii Acknowledgements . .. . iv Table of Contents .. . v List of Figures . . .. vi List of Abbreviations ... .. vii Introduction . ... 1 Chapter I: Literature Review . .... 4 I. Atrial Natriuretic Peptide .. 4 A. Introduction . 4 B. ANP ...
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ژورنال
عنوان ژورنال: The Veterinary Journal
سال: 2010
ISSN: 1090-0233
DOI: 10.1016/j.tvjl.2009.02.011